The British Menopause Society (BMS) has issued an update on HRT supply to provide guidance on the current availability of HRT products. The information on stock availability and supplies was obtained by the BMS from the pharmaceutical companies manufacturing the products.
Besins Healthcare (UK) HRT products
- Oestrogel® (estradiol) Pump-pack. Supply issues
- Utrogestan (micronised progesterone) 100 mg in continuous combined regimen and 200 mg in sequential regimens. Available
- Testogel 50 mg, gel sachet (sachet over 10 days to provide 5 mg a day). Available
- Testogel 40.5 mg gel sachet – a new sachet preparation – Now available. Sachet over 8 days to provide 5 mg a day. Off-label use for female testosterone replacement (5 mg a day).
- Imvaggis vaginal 0.03 mg estriol vaginal pessary. Available
Gedeon Richter
- Lenzetto x1 pack. Temporary shortage expected to be resolved in April 2022.
- Lenzetto x3 pack. Available
- Vagirux 10 micrograms vaginal tablets. Available.
Orion HRT products
Due to unprecedented demand over recent months, Orion has announced that it has experienced some supply issues with Sandrena Gel. The company continues to receive regular supplies of all HRT products from its European parent company and is working to manage and increase supplies for the UK.
It anticipates that all products will be back in stock by the end of May 2022.
- Sandrena 0.5 mg estradiol sachet (28x packs). Available
- Sandrena 1.0 mg estradiol sachet (28x packs). Available
- Sandrena 1.0 mg estradiol sachet (91x packs). Unavailable
- Indivina 1mg estradiol + 2.5mg medroxyprogesterone acetate. Available
- Indivina 1mg estradiol + 5mg medroxyprogesterone acetate. Available
- Indivina 2mg estradiol + 5mg medroxyprogesterone acetate. Available
- Tridestra 2mg estradiol + 20mg medroxyprogesterone acetate. Available
Theramex HRT products
- Bijuve (estradiol/progesterone). Available
- Evorel® Conti (estradiol/norethisterone). Available
- Evorel® Sequi (estradiol/norethisterone). Available
- Evorel® 25 (estradiol). Available
- Evorel® 50 (estradiol). Available
- Evorel® 75 (estradiol). Available
- Evorel® 100 (estradiol). Available
- FemSeven® Conti (estradiol/levonorgestrel). Available
- FemSeven® Sequi (estradiol/levonorgestrel). Expected June 2022
- FemSeven® 50 (estradiol). Available
- FemSeven® 75 (estradiol). Available
- FemSeven® 100 (estradiol). Expected May 2022
- Intrarosa® (Prasterone). Available
- Zoely® (nomegestrol acetate/estradiol). Available
Novartis pharmaceuticals
- Estradot TTS-75. Available
- Estradot TTS-25. Available
- Estradot TTS-37.5. Available
- Estradot TTS-50. Available
- Estradot TTS-100. Available
- Estradot 37.5mg. QA released and available to order.
Norgine UK – Estraderm MX patches
- Estraderm MX estradiol 25 patches. Available
- Estraderm MX estradiol 50 patches. Available
- Estraderm MX estradiol 75 patches. Available
- Estraderm MX estradiol 100 patches. Available
Viatris UK Healthcare (previously Mylan)
- Femoston® 1mg estradiol + 10mg dydrogesterone. Available
- Femoston® 2mg estradiol + 10mg dydrogesterone. Available
- Femoston®-conti 1mg estradiol + 5mg dydrogesterone. Available
- Femoston®-conti ultra-low dose 0.5mg estradiol + 2.5mg dydrogesterone. Available
- Zumenon® 1mg estradiol. Available
- Zumenon® 2mg estradiol. Available
- Elleste Solo™ 1mg estradiol. Available
- Elleste Solo™ 2mg estradiol. Available
- Elleste Duet™ 1mg estradiol + 1mg norethisterone acetate. Available
- Elleste Duet™ 2mg estradiol + 1mg norethisterone acetate. Available
- Elleste Duet™ Conti 2mg estradiol + 1mg norethisterone acetate. Available
- Elleste Solo™ MX patches 40mcg transdermal estradiol No longer available (discontinued) (contact Viatris for more information)
- Elleste Solo™ MX patches 80mcg transdermal estradiol No longer available (discontinued) (contact Viatris for more information)
Pfizer
- Duavive. Conjugated equine estrogen 0.45 mg + 20 mg bazedoxifene. Discontinued.
Other Pfizer HRT products. Available
Novo Nordisk HRT products
- Kliovance 1mg estradiol + 0.5mg norethisterone acetate. Available
- Kliofem 2mg estradiol + 1mg norethisterone acetate. Available
- Novofem 1 mg estradiol + 1 mg norethisterone acetate. Available
- Trisequens 2mg/2mg/1mg estradiol + 1mg norethisterone acetate. Available
- Vagifem 10mcg topical vaginal estrogen. Available
Bayer
- Progynova 1mg estradiol tablets. Low stock, but available after 28.03.2022
- Progynova 2 mg estradiol tablets. Low stock but currently available, improvement after 11.04.2022
- Progynova TS estradiol 50 patches. Available
- Progynova TS estradiol 100 patches. Available
- Mirena IUS. Available
- Qlaira. Available
Endo Pharmaceuticals
- Testim testosterone gel. 50 mg tube. Available. Off-label use for female testosterone replacement (5 mg a day).
Aspen
- Ovestin. Estriol topical vaginal cream. Available
Marlborough
- Estriol 0.01%. Topical Estriol vaginal cream. Available
Flynn Pharma Ltd
- Blissel 50 micrograms estriol vaginal gel. Available
Shionogi BV
- Senshio (ospemifene) 60mg 28 tablet pack – Available
Shionogi UK has decided to discontinue commercial support behind Senshio (ospemifene). However, Shionogi Europe will continue to support existing and upcoming formulary applications through the EU Med Affairs and Senshio remains available to prescribe in the UK for patients who need it.
Kyowa Kirin Ltd
- Tostran 2% Gel. Available Female testosterone replacement (10 mg per measure to take 2-3 times a week).
Lawley Pharmaceuticals
- AndroFeme 1 testosterone 1% cream (Specials unlicensed supply). Available UK ‘specials’ status remains.
On 23rd November 2020 Australia’s regulatory granted AndroFeme 1 full marketing authorisation and registration on the Australian Register of Therapeutic Goods. The approved indication for the management of hypoactive sexual desire dysfunction (HSDD) in postmenopausal women.
MSD
- Livial (2.5 mg Tibolone) (x84 packs). Available
- Livial (2.5 mg Tibolone) (x28 packs). Available
Further information is available from the BMS website.
Clinicians can also access the PCHWF Guidance on management and prescribing HRT for GPs.