Gedeon Richter has announced the launch of a new transdermal HRT spray in the UK. Lenzetto (estradiol spray) is for symptoms of oestrogen deficiency in post-menopausal women, at least six months since last menses or surgical menopause, with or without a uterus.[i] Estradiol spray is applied to the skin and is specifically designed to be delivered as an oestrogen spray.[i]
Around 13 million women in the UK are either peri- or post-menopausal, and symptoms can last up to 15 years.[ii] In a study conducted by Nuffield Health, it was found that 60% of women experience symptoms resulting in behaviour changes with two thirds of women feeling that there is a general lack of support or understanding.[ii]
In clinical studies, estradiol spray has met its primary endpoint of mean change from baseline for both the frequency and severity of hot flushes, with adverse events reported comparable to other transdermal products.[iii] Estradiol spray has also met pharmacological endpoints, with the product delivering estradiol at a therapeutic level.[iv]
Dr Kathrine Scott, Medical Director at Gedeon Richter UK, said: “Gedeon Richter are very pleased to be able to offer this new HRT, which we hope gives more options to healthcare professionals and women. The availability of estradiol spray means that women who are experiencing menopausal symptoms have a greater variety of potential treatments that could improve their quality of life.”
“The decision to make estradiol spray available on the NHS is a positive step for both patients and clinicians,” said Tamás Neubauer, Managing Director at Gedeon Richter. “We are excited about this new treatment being made available across the UK, and hope it has a positive impact for women.”
[i] EMC. Lenzetto 1.52mg/spray, transdermal spray, solution. Available at: https://www.medicines.org.uk/emc/product/11175/smpc. Last accessed: April 2020.
[ii] Menopause support. Facts. Available at: https://menopausesupport.co.uk/?page_id=60. Last accessed: April 2020.
[iii] Buster JE, Koltun WD, Pascual ML, Day WW, Peterson C. Low-dose estradiol spray to treat vasomotor symptoms: a randomized controlled trial. Obstet Gynecol. 2008;111:1343-1351.
[iv] Morton TL, Gattermeir DJ, Petersen CA, Day WW, Schumacher RJ. Steady-state pharmacokinetics following application of a novel transdermal estradiol spray in healthy postmenopausal women. J Clin Pharmacol. 2009;49:1037-1046.