Endometrial cancer is the most common gynaecological cancer in high-income countries.
This study provides insight into potential causal mechanisms linking body mass index (BMI) with endometrial cancer risk. In comparison to previous conventional observational studies, the findings from this study demonstrated that a lifelong elevated BMI causes a larger increased risk.
These results suggest targeting insulin-related and hormonal traits as a potential strategy for the prevention of endometrial cancer.
Source: BMC Medicine